Mary L. Bouxsein, PhD is Professor of Orthopedic Surgery at Harvard Medical School and Director of the Center for Advanced Orthopedic Studies at Beth Israel Deaconess Medical Center. Her group has focused on understanding the biomechanics of skeletal fragility, including age-related fractures and stress fractures due to novel physical activity. Her team aims to gain insight into the contribution of mechanical loading to fracture risk via advanced subject-specific musculoskeletal modeling. She has used non-invasive imaging technologies to characterize bone microstructure in animal models and in humans, and has show the contribution of bone microstructure to skeletal fragility in several clinical scenarios. In addition, her group has studied the impact of unloading and microgravity on the musculoskeletal system. Dr. Bouxsein is a Fellow of the American Society for Bone and Mineral Research, and has served on the Council of the ASBMR and the Board of the International Osteoporosis Foundation. She has received funding from the NIH, NASA and the Department of Defense. Dr. Bouxsein has published over 350 peer-reviewed manuscripts.